Neuronal Circuit Activity during Neonatal Hypoxic–Ischemic Seizures in Mice
نویسندگان
چکیده
منابع مشابه
Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures.
Seizures induce excitatory shifts in the reversal potential for GABA(A)-receptor-mediated responses, which may contribute to the intractability of electro-encephalographic seizures and preclude the efficacy of widely used GABAergic anticonvulsants such as phenobarbital. We now report that, in intact hippocampi prepared from neonatal rats and transgenic mice expressing Clomeleon, recurrent seizu...
متن کاملCerebral blood flow velocity during neonatal seizures.
AIM To determine if cerebral blood flow velocity increases during all types of neonatal seizure, and whether the effect is due solely to an increase in blood pressure, transmitted to the cerebral circulation when autoregulation is impaired. METHODS Seizures were diagnosed in 11 high risk neonates using cotside 16 channel video-EEG polygraphy. EEG, cerebral blood flow velocity (CBFV) using tra...
متن کاملDecreased neuronal synchronization during experimental seizures.
Synchronization between CA1 pyramidal neurons was studied using dual-cell patch-clamp techniques simultaneous with an extracellular measurement of network activity. We explored various linear and nonlinear methods to detect weak synchronization in this network, using cross-correlation, mutual information in one and two dimensions, and phase correlation in both broad and narrow band. The linear ...
متن کاملNeonatal seizures
The incidence of seizures in infants born at term is 0.53 per 1000 live births; the incidence is even higher in preterm infants, ranging from 113% of very low birthweight infants3. Variations of described numbers of incidence can be explained by different diagnostic definitions and methods used. Most of these epidemiological studies include only clinical seizures. The exact incidence of elect...
متن کاملNeonatal seizures.
In childhood, the risk for seizures is greatest in the neonatal period. Currently used therapies have limited efficacy. Although the treatment of neonatal seizures has not significantly changed in the past several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This review includes an...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2019
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.25601